About

Why OrthoFinder?

In the coming decades, millions of species will have their genomes sequenced. This data has the power to transform comparative genomics, but we need scalable tools to handle this volume of data. OrthoFinder meets this challenge, with a new scalable framework that allows rapid orthology inference on thousands of species, without compromising accuracy. We focus on:

• Accuracy

OrthoFinder is the overall best performing tool across orthogroup and ortholog benchmarking.
• Scalability

OrthoFinder allows you to analyse thousands of species on conventional computing resources.
• Usability

OrthoFinder only requires a single fasta file for each species, and outputs a vast array of comparative genomic information including gene trees and gene duplication events.
• Flexibility

Users can easily swap to different tree-inference and multiple sequence alignment tools, thanks to OrthoFinder’s modular design.

Development and community

OrthoFinder is developed by Steve Kelly’s research group at the University of Oxford. We have an active community of users and developers on GitHub, who can provide help and assistance